Laboratory and Clinical Medicine. Pharmacy
Scientific and practical quarterly peer-reviewed journal
ISSN 2712-9330 (Online)
ISSN 2712-9330 (Online)
There is a barrier to understanding the causes of infertility in couples timely due to asymptomatic picture of high risk human papillomavirus (hrHPV) in men. Concerning to recent research, hrHPV capsids bind efficiently to two distinct sites at the equatorial region of the sperm head surface. The clinical case demonstrates the role of sperm sediment cytology in diagnostics of hrHPV that was confirmed by hrHPV screening test by nucleic acid amplification technique (NAAT) with polymerase chain reaction in real time (RT-PCR) (NAAT/ RT-PCR/hrHPV).
Cytological examination of fine-needle biopsy material from neck tumors is used for primary diagnosis of the type of formation and determination of further tactics for patient management. This clinical case presents a rare combination of mucoepidermoid carcinoma of the salivary gland and diffuse large B-cell lymphoma in one patient. Cytological examination allowed us to establish a preliminary diagnosis of a primary multiple tumor.
Oncocytic tumors amount for about 5 % of thyroid cancer. Oncocytic differentiation of cells can be observed in various benign processes, as well as in various neoplasms of the thyroid gland (for example, in papillary, medullary carcinomas), which can cause a number of difficulties and predetermine the need for thorough differential diagnosis during cytological examination.
The article presents a clinical and morphological features of the case of oncocytic thyroid carcinoma, demonstrating the difficulties of its diagnostics at the preoperative stage and the possibility of urgent intraoperative cytological diagnostics of this tumor, the results of which correlate with the conclusion of a subsequent histological examination.
Cytology is known to be a highly effective method of diagnosis of lung metastases. The cytomorphological criteria for lung metastases of malignant melanoma are known and described in the literature, but are few in number and there are some objective difficulties in the differential diagnosis of malignant melanoma metastases of other lung lesions.
This paper presents a clinical and morphological case of MM metastasis and demonstrates the high efficiency of the traditional (classical) cytological method in its diagnosis according to established the cytomorphological criteria, which complements the data from the literature.
Introduction. Distant metastases of malignant neoplasms of various organs, including melanoma, are common in the bronchopulmonary system. Cytological examination as a minimally invasive and highly effective method has an important place in the diagnosis of malignant melanoma metastases in the lungs.
Case Presentation. This article presents a clinical and morphological case of metastatic lung melanoma in a 73-year-old man. Cytological examination of fine needle biopsy samples was used to assess the lesion.
Conclusion. This work demonstrates the high efficiency of the cytological method for the diagnosis of lung metastasis from malignant melanoma metastases. The cytomorphological changes established in the study are comparable to the data from the literature and complement them.
The presented case demonstrates the importance of a comprehensive analysis of all the examination data in a patient with paroxysmal nocturnal hemoglobinuria (PNH). A comparison was made of anamnesis data, the clinical picture of the disease, the results of biochemical blood analysis and hematological analyzer data with morphological assessment of cells in a stained blood smear. The interest of this case for hematologists and laboratory specialists is due to the rarity of this disease, difficulties in diagnostics, the presence of 2 types of hemolysis, features of morphological changes in peripheral blood erythrocytes, as well as analysis of the dynamics of manifestations, including against the background of targeted therapy of PNH.
Essentialy, the diagnostics feature of myeloproliferative neoplasms (MPNs) is a genetic mutations. While bcr-abl translocation belongs to CML, Jak2V617F mutation is commonly associated with other MPNs. The recent decade has been clarified a data when a human blood presents bcr-abl translocation and Jak2V617F mutation both. This clinical case reports of bcr-abl translocation and Jak2V617F mutation when they were detected simultaneously by polymerase chain reaction (PCR) in a patient with myeloproliferative neoplasm, unclassifiable (MPN-U).
Introduction. Primary pulmonary lymphoepithelial carcinoma is a poorly differentiated squamous cell carcinoma admixed with variable amounts of lymphoplasmacytic infiltrate, frequently associated with EBV. It is a rare cancer and have a better prognosis than other non-small cell lung cancer. The tumor can mimic metastatic non-keratinizing SCC of the naso-pharynx, poorly differentiated non-small cell carcinoma and NUT carcinoma arising in the lung, and non-Hodgkin
lymphomas.
Materials and methods. A 75-year-old man presented with peripheral mass of left lower lobe, maximal diameter was 5.1 cm, involving lingula and medial pleura, with mediastinal, and retroperitoneal lymphadenopathy revealed by computer tomography. Fine needle aspiration-EBUS was performed from hilar and interlobar lymph nodes. Papanicolaou smears
and cell blocks were prepared. Additional CT-guided cor-needle biopsy and FNA were performed from lung lesion later.
Results. A few large malignant epithelial cells, consistent with non-small lung cancer, were found on a background
of lymphocytes in fine-needle aspiration from lymph nodes. Immunostain results: Pan-CK (AE1/AE3), p63 and Ki67
were positive in malignant cells, leukocyte common antigen (CD45) was positive in lymphocytes (negative in tumor cells), and negative markers were TTF1, chromogranin and synaptophysin. Cytological diagnosis was metastatic non-small lung cancer, favor squamous cell carcinoma. Biopsy and aspiration from left lung showed syncytial groups of large malignant epithelial cells with scant cytoplasm and prominent nucleoli on a background of prominent inflammatory infiltrate,
consistent with lymphoepithelial carcinoma.
Conclusion. It is impossible to correctly diagnose metastasis of lymphoepithelial carcinoma in lymph node by FNA only without FNA or biopsy of primary lesion, because cytological features and immunostains are identical to non-keratinizing squamous cell carcinoma.
Merkel cell carcinoma is a rare malignant primary skin tumor with epithelial and neuroendocrine differentiation.
In the presented diagnostic case, the possibility of a cytological method in this material is a scarification biopsy.
Journal of the International Cytology School and Innovatory Medical School
Journal of the International Cytology School and Innovatory Medical School
