Laboratory and Clinical Medicine. Pharmacy

Scientific and practical quarterly peer-reviewed journal

 

ISSN 2712-9330 (Online)

VOL 4, No. 4 (2024)

lcmp_2024_04_recl

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    Economics and Management in Medicine and Pharmacy

  • MARKETING RESEARCH OF THE FEDERAL AND REGIONAL MARKET OF HEPATOPROTECTORS

    Autors: Aydova A. V. , Shakirova D. K. , Abdulhakov S. R.
    • Pages: 8-13
    • Views: 19
    The results of a marketing research study are presented in this article. Аt both federal and regional levels, the pharmaceutical market for hepatoprotectors is available. Аn overall measure of the breadth, completeness and depth assortments of hepatoprotectors. Data on the number of medicines with hepatoprotective properties. The sales volume of a group of hepatoprotectors in the Russian Federation in 2020 – 2022 has been determined.

    • Critical Review

  • SEMEN EXAMINATION ON THE NATIONAL WAY

    Autors: Sapozhkova Z. Y.
    • Pages: 14-25
    • Views: 19
    Over the past two decades scientific and practical research and developments by Russian laboratory medicine specialists have been shown evolutionary and revolutionary achievements in the field of male infertility (MI) diagnostic technologies. Todays the current national guidelines contain information on laboratory research methods which should be reviewed and updated considering a key opinion leader of laboratory medicine. Review contains a detailed analysis of the clinical recommendations of the Ministry of Health of Russian Federation, the standard of medical care, GOST R ISO 23162–2023 and other normative legal documents which based on the algorithm of laboratory evaluation a cause of MI in ejaculate samples.

    • Original Articles

  • THE STUDY OF CORRELATION WOUND BED pH FROM WOUND PROCESS STAGE

    Autors: Mishina E. S. , Grigoryan A. Y. , Zatolokina M. A. , Kudryavtseva T. N. , Efanov S. A. , Soroka V. V.
    • Pages: 26-32
    • Views: 20
    Relevance. During the regeneration of a skin wound there is a changing an inflammation phases and chemical content, as a result, a pH shift. Study of dependence the stage of the wound process from pH of the wound bed is increasable important for medication strategy by drags which changing pH and accelerate the healing of a skin wound.
    Materials and methods. The experiment was performed by modeling a purulent wound in 36 animals – a Wistar rat. Further, on the 1st, 3rd, 5th, 8th, 10th and 15th days of the experiment, the pH of the wounds was determined and autopsy material was collected for subsequent histological examination. The obtained sections were stained with hematoxylin and eosin, a descriptive assessment of the wound defect was performed, as well as the calculation of cellular components.
    Results. The wound bed was filled with purulent necrotic masses on the 3rd day of the experiment, while the cellular composition was mainly represented by granulocytes and macrophages. At the same time, the pH measurement has been determined the value of 7.64 (7.48; 7.81), cellular index (CI) 0.4 (0.36; 0.43). From the 8th day of the experiment a morphometric study has been showed the spontaneous healing of a purulent wound with changing an exudative phase to proliferative one. That point has been confirmed the CI 1.3 (1.25; 1.41) witch pH acidification to 7.39 (7.20;7.76).
    Conclusion. According to the study, when the pH value decreases, it leads to an increase in the number of fibroblastic cells and has a beneficial effect on the course of the wound process.

  • FEATURES OF DENTAL HARD TISSUE AND PERIODONTIUM CONDITION IN PATIENTS WITH SJOGREN’S DISEASE AND SJOGREN’S SYNDROME

    Autors: Losev F. F. , Leontiev V. K. , Abramova E. S. , Selifanova E. I. , Smirnova L. E.
    • Pages: 33-40
    • Views: 29
    This study presents the results of evaluation of the intensity and prevalence rate of dental hard tissue diseases, periodontal pathology, parotid glands secretory activity in patients with systemic autoimmune rheumatic diseases such as Sjogren’s disease (SD) and Sjogren’s syndrome (SS).
    The aim is the evaluation of intensity and prevalence rate of dental hard tissue diseases and inflammatory periodontal diseases according to the parotid glands secretory activity in patients with SD and SS.
    Materials and methods. A comprehensive clinical and dental examination of 85 patients with SD, 139 with SS was performed (rheumatoid arthritis (RA) + SS – 49; systemic lupus erythematosus (SLE) + SS – 52; systemic scleroderma (SSD) + SS – 38). Patients underwent in comprehensive dental examination, which included the complaints collection, medical history, assessment of conditions of dental hard and periodontal tissues. The functional ability of the parotid glands was evaluated by M. V. Simonova’s method.
    Results. As a result of the clinical examination, the highest caries rates, ranging from 3 to several tooth surfaces (K.02) was revealed, which typically for patients with SD and SS, cervical caries was suffered to a greater extent by patients with SD (85.0 %). With SD, they were most often observed: increased abrasion of mixed-type tooth enamel, enamel chips and wedge-shaped defects in 20.0 %, 18.8 % and 7.1 % of cases. In patients with SSH (RA + SSH, SLE + SSH, SSD + SSH), increased abrasion of mixed-type tooth enamel was detected in 18.4 %, 16.0 %, 10.8 %, enamel chips – 6.1 %, 14.0 %, 5.4 %, the presence of wedge–shaped defects – 4.0 %, 4.1 %, 0 %, respectively. A low level of hygiene was noted in all the examined groups, but a high percentage was observed in 37 (97.4 %) patients with SSD + CS and 61 (71.8 %) and in patients with BS. The main form of periodontal pathology is chronic periodontitis of moderate severity, the index (PI) for SD is 1.3 [1.2; 1.5], SH is 1.3 [0.9; 2.0]. When comparing the results of the functional state of the parotid glands by sialometry, a significant quantitative difference was noted between the groups with SD 1.3 [0.5; 2.1] ml and SS + immuno-inflammatory rheumatic diseases (IIRD) 2.0 [0.9; 3.5] ml, SS + SLE 2.4 [1.7; 4.0] ml.
    Conclusion. As a result of a comprehensive oral examination in patients with SD and SS + IIRD, a high prevalence and intensity of caries and non-caries, affected dental hard tissues, and inflammatory periodontal diseases were revealed.
    The level of dental care for patients with SD and SS + IIRD remains limited.
    Comparing groups of patients with SD and SS + IIRD, we revealed significant differences in the secretory activity of parotid glands, the presence of rapidly progressive multiple, cervical and circular caries, as well as defects of enamel including chipped tooth enamel and dental erosions in patients with SD in contrast to patients with SS + IIRD.

    • Clinical Case

  • CYTOLOGICAL DIAGNOSTICS OF VULVAR MALIGNANT MELANOMA. CASE REPORT

    Autors: Skugar-Skvarskaya S. A. , Kireev A. А. , Dostieva S. M.
    • Pages: 41-46
    • Views: 19
    Vulvar malignant melanoma is a rare disease and poses a serious problem for women's health. This pathology is characterized by a high degree of malignancy and an unfavorable prognosis. The article presents a clinical observation demonstrating the possibilities of cytological examination to detect vulvar melanoma in a 67-year-old patient.

  • MULTIDISCIPLINARY APPROACH TO MORPHOLOGICAL DIAGNOSIS OF MELANOMA. CASE REPORT

    Autors: Vysotskaya V. N. , Haiduk I. I. , Sapozhkova Z. Y. , Kasoyan K. T.
    • Pages: 47-54
    • Views: 22
    Melanoma is one of the most difficult skin tumours to diagnose cytologically and histologically. The accuracy of the examination results in the diagnostic process with cutaneous melanoma depends on strict compliance with the technological procedures of the pre-analytical extra-laboratory stage – adequacy of the obtained material; pre-analytical laboratory stage – correct sample preparation and quality staining of biopsy and surgical material; analytical laboratory stage – expertise of the pathologist in dermatopathology; post-analytical stage – selection of the necessary further diagnostic tactics, namely, the implementation of ancillary procedures; and the use of auxiliary procedures. The key role is given to interdisciplinary interaction between cytologists and pathologists in verification of melanoma diagnosis.

    • Review Articles

  • SCIENTIFIC PUBLICATIONS AND DISSERTATION DEFENSE IN THE SPECIALTY 1.5.22 ‘CELL BIOLOGY’: THE CURRENT STATE OF THE ISSUE

    Autors:

    Blagonravova A. S. , Loginova N. P. , Barkovskii M. M. , Artemeva V. A. , Sosnin D. Y.

    • Pages: 55-68
    • Views: 22

    The article presents an analysis of dissertation councils accepting dissertations in the specialty 1.5.22 – cell biology and the publication activity of journals included in the List of peer-reviewed scientific publications in which scientific results of dissertations for the degree of candidate of Sciences, for the degree of Doctor of Sciences (as of 07/08/2024) should be published. The distribution of dissertation councils by federal districts of the Russian Federation and branches of science is shown. For periodicals, their attractiveness in publishing the results of scientific research is considered. The article presents the characteristics of journals from the point of view of choosing a publication for the placement of dissertation research materials, and also considers the attractiveness of periodicals for publishing the works of the teaching staff of scientific and educational institutions from the point of view of fulfilling an effective contract.

    • History of Medicine and Pharmacy

  • SEMEN EXAMINATION HISTORY: FROM THE ERA OF INITIAL KNOWLEDGE ACQUISITION TO LABORATORY MANUAL. PART I

    Autors: Sosnin D. Y. , Sapozhkova Z. Y. , Chelikova G. A.
    • Pages: 69-74
    • Views: 18
    The current achievements in human semen examination have gone a way in 3.5 century duration. Understanding and analyzing scientific discoveries of the past, acquaintance with scientists of the era of accumulation of initial knowledge about semen samples are paramount and mandatory for protection and improvement of demography globally. The first part of the review is presented which clarifies historical fragments from origin idea of semen examination to emergence of laboratory manual.
Баннер снизу

Editor-in-chief

Zhanna Yu. Sapozhkova

Journal of the International  Cytology School and  Innovatory Medical School

Journal of the International  Cytology School and  Innovatory Medical School