Laboratory and Clinical Medicine. Pharmacy

Scientific and practical quarterly peer-reviewed journal

 

ISSN 2712-9330 (Online)

VOL 5, No. 3 (2025)

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    Economics and Management in Medicine and Pharmacy

  • ANALYSIS OF VECTORS OF COOPERATION OF HEALTHCARE PROFESSIONALS IN PHARMACOTHERAPY OF PATIENTS WITH ARTERIAL HYPERTENSION

    Autors: Razdorskaya I. M. , Mal G. S.
    • Pages: 4-14
    • Views: 171
    Objective. To examine the collaboration between physicians and pharmaceutical professionals in the provision of pharmacotherapy for patients with cardiovascular diseases, particularly arterial hypertension (AH). Materials and Methods. A comparative analysis of the structure and workflow of medical (MO) and pharmacy (PO) organizations in Kursk city and region was performed. The study included a survey of healthcare professionals involved in the medication provision process. Results. Significant discrepancies were identified between the prescribed and dispensed medications in four pharmacological groups, indicating insufficient coordination between physicians and pharmacy staff. Professional profiles of physicians and pharmacists were developed to characterize their roles in managing patients with AH. The study also highlighted the relevance of non-pharmacological approaches to disease management, including the improvement of patient compliance through counseling, identifying physical and psychological barriers to treatment, and preventive work with healthy individuals visiting pharmacies. Conclusion. The findings emphasize the need for close collaboration between physicians and pharmaceutical professionals, based on cross-communication and shared decision-making in the management of patients with arterial hypertension.

  • A NOVEL LABORATORY ALGORITHM FOR COMPREHENSIVE SEMEN ANALYSIS. PART 1

    Autors: Sapozhkova Z. Yu. , Dolgov V. V.
    • Pages: 15-22
    • Views: 168
    A clinical-laboratory algorithm has been developed and implemented in practice, based on a comprehensive analysis of ejaculate and its sediment through multilevel diagnostics integrating chemical-microscopic, functional, metabolic, molecular, and microbiological semen parameters into a single diagnostic model. The algorithm’s stages are sequential, with the application of each stage determined situationally and personalized, taking into account the rationale for selection and the priority of the objectives set. The use of a single non-invasive biomaterial – ejaculate – has made the patient examination process completely painless, stress-free, and rapid, while maintaining maximum diagnostic depth. This concept transforms the paradigm of the previous traditional approach to semen analysis, establishing a clear diagnostic pathway toward a personalized strategy for correcting identified disorders and optimizing the diagnostic process prior to the prescription of costly and invasive procedures.

    • Original Articles

  • MODULATION OF THE TGF-β SIGNALING PATHWAY IN THE TREATMENT OF ENDOMETRIAL HYPERPLASIA WITH GESTAGENS

    Autors:

    Sarkisyan R. M.
    • Pages: 23-33
    • Views: 117

    Objective. This study aimed to investigate the effect of progestogens on key components of the transforming growth factor beta (TGF-β) signaling pathway in the endometrial mucosa in cases of non-atypical endometrial hyperplasia, in order to determine the pathogenetic role of this pathway and to predict treatment outcomes. Materials and Methods. A comprehensive examination was conducted on 19 patients with non-atypical endometrial hyperplasia before and after 3 months of conservative treatment with progestogens. Endometrial samples were obtained by dilatation and curettage or Pipelle biopsy. Results. The study revealed that progestogens suppress the upregulated expression of TGF-β observed in endometrial hyperplasia and modulate the altered expression of other components of the TGF-β-dependent signaling pathway, particularly SMAD proteins ( From the name of the Drosophila MAD gene (mothers against decapentaplegic) and the Caenorhabditis elegans SMA gene (small worm phenotype), restoring them to levels typical of normal endometrium. Conclusion. These findings confirm that components of the TGF-β signaling pathway are altered in endometrial hyperplasia and are sensitive to modulation by progestogen therapy. This opens new perspectives for the treatment of this condition and for the prevention of malignant transformation of the endometrial lining leading to endometrial carcinoma.

    • Clinical Case

  • SEROUS CYSTADENOMA OF ECTOPIC OVARY. CLINICAL CASE REPORT

    Autors: Belkin A. N. , Yakovleva E. V.
    • Pages: 34-39
    • Views: 170
    Ectopia of the ovary is a rare variant of anomaly of the uterine appendages, characterized by the localization of the ovary in an atypical anatomical area. This disease is most often an accidental finding during instrumental examination of the patient. Clinical manifestations of this anomaly are nonspecific and characterized by chronic pain syndrome, that occurs with cystic or neoplastic transformation of the organ. We present a clinical case of 63-year-old patient with benign tumor – serous cystadenoma of the right ectopic ovary, localized in the mesentery of the ileum. Morphological examination of the material allowed to clarify the essence of pathological changes.

  • DIFFICULTIES IN DIAGNOSIS OF A RARE VARIANT OF ACUTE ERYTHROID LEUKEMIA. MORPHOLOGICAL, CYTOCHEMICAL AND IMMUNOPHENOTYPIC CHARACTERISTICS OF AN ATYPICAL MYELOGRAM. A CLINICAL CASE

    Autors: Makarchev A. I. , Chekasina A. A. , Stuklov N. I. , Lugovaya E. O. , Gimadiev R. R. , Gubina E. V. , Chausova S. V. , Kostina M. A.
    • Pages: 40-46
    • Views: 162
    A case of acute erythroid leukemia (AEL) is described in a 75-year-old female patient with cytopenia and bone marrow infiltration with undifferentiated blast cells (?50 %) with decreased bone marrow cellularity. Cytochemical analysis revealed a predominance of a diffusely granular pattern in the periodic acid–Schiff (PAS) reaction, which is atypical for AEL and complicated the cytomorphological diagnosis. The diagnosis was confirmed by immunophenotyping. The case highlights the variability of morphological characteristics in the diagnosis of atypical variants of AEL.

  • VALIDATION OF NEWLY DEVELOPED LABORATORY ALGORITHM FOR COMPREHENSIVE SEMEN ANALYSIS: A CASE SERIES (PART 2)

    Autors: Sapozhkova Z. Yu. , Dolgov V. V.
    • Pages: 47-54
    • Views: 106
    Clinical cases confirm the diagnostic effectiveness of the comprehensive approach and the importance of timely identification of the source of reproductive dysfunction. Despite the diagnostic performance indicators of each method within the algorithm, a personalized approach to every clinical case remains fundamentally important. Such an integrative strategy is particularly valuable in reproductive medicine, where the cost of diagnostic error can be critically high for both fertility prognosis and the patient’s psycho-emotional well-being.
Баннер снизу

Editor-in-chief

Zhanna Yu. Sapozhkova

Journal of the International  Cytology School and  Innovatory Medical School

Journal of the International  Cytology School and  Innovatory Medical School