Cytology is known to be a highly effective method of diagnosis of lung metastases. The cytomorphological criteria for lung metastases of malignant melanoma are known and described in the literature, but are few in number and there are some objective difficulties in the differential diagnosis of malignant melanoma metastases of other lung lesions.
This paper presents a clinical and morphological case of MM metastasis and demonstrates the high efficiency of the traditional (classical) cytological method in its diagnosis according to established the cytomorphological criteria, which complements the data from the literature.
Introduction. Distant metastases of malignant neoplasms of various organs, including melanoma, are common in the bronchopulmonary system. Cytological examination as a minimally invasive and highly effective method has an important place in the diagnosis of malignant melanoma metastases in the lungs.
Case Presentation. This article presents a clinical and morphological case of metastatic lung melanoma in a 73-year-old man. Cytological examination of fine needle biopsy samples was used to assess the lesion.
Conclusion. This work demonstrates the high efficiency of the cytological method for the diagnosis of lung metastasis from malignant melanoma metastases. The cytomorphological changes established in the study are comparable to the data from the literature and complement them.
Irina P. Shabalova – MD, PhD, the Russian Medical Academy of Continuing Professional Education of the Russian Ministry of Health, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Andrey A. Kireev – MD, PhD, cytologist, the Russian Medical Academy of Continuing Professional Education of the Russian Ministry of Health, Clinical Diagnostic Laboratory of the Yudin S.S. Clinical Hospital of The Moscow Health Department, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
1. Domagala-Kulawik J. The relevance of broncho-alveolar lavage fluid analysis for lung cancer patients. Expert Rev Respir Med. 2020Mar;14(3):329-37. DOI: 10.1080/17476348.2020.1708720
2. Auger M, Brimo F, Kanber Y, et al. A practical guide for ancillary studies in pulmonary cytologic speci-mens. Cancer Cytopathol. 2018Aug;126(Suppl 8):599-614. DOI: 10.1002/cncy.22028
3. Grigorenko AA, Voytsekhovskiy VV, Roshchin SN, et al. Melanoma with respiratory damage. Bulletin Physiology and Pathology of Respiration. 2022;(83):81-90. (In Russ). DOI: 10.36604/1998-5029-2022-83-81-90
4. Ronchi A, Montella M, Zito Marino F, et al. Cytologic diagnosis of metastatic melanoma by FNA: A practical review. Cancer Cytopathol. 2022Jan;130(1):18-29. DOI: 10.1002/cncy. 22488
5. Ali Z, Yousaf N, Larkin J. Melanoma epidemi-ology, biology and prognosis. EJC Suppl. 2013Sep;11(2):81-91. DOI: 10.1016/j.ejcsup.2013.07.012
6. Reed KB, Brewer JD, Lohse CM, et al. Increasing incidence of melanoma among young adults: an epidemio-logical study in Olmsted County, Minnesota. Mayo Clin Proc. 2012Apr;87(4):328-34. DOI: 10.1016/j.mayocp.2012.01.010
7. Rebecca VW, Somasundaram R, Herlyn M. Pre-clinical modeling of cutaneous melanoma. Nat Commun. 2020Jun5;11(1):2858. DOI: 10.1038/s41467-020-15546-9
8. Guy GP Jr, Thomas CC, Thompson T, et al. Vital signs: melanoma incidence and mortality trends and projections United States, 1982-2030. MMWR Morb Mortal Wkly Rep. 2015;64:591-6.
9. Shi Y, Bing Z, Xu X, et al. Primary pulmonary ma-lignant melanoma: Case report and literature review. Thorac Cancer. 2018Sep;9(9):1185-9. DOI: 10.1111/1759-7714.12798
10. National Comprehensive Cancer Network (NCCN). NCCN website. Available at: http://www.nccn.org/index.asp Accessed: 30 April 2021.
11. Pagliuca F, Ronchi A, Cozzolino I, et al. Mesenchymal neoplasms: Is it time for cytology? New per-spectives for the pre-operative diagnosis of soft tissue tu-mors in the molecular era. Pathol Res Pract. 2020;216(6):152923. DOI: 10.1016/j.prp.2020
12. Hall BJ, Schmidt RL, Sharma RR, et al. Fine-needle aspiration cytology for the diagnosis of metastatic melanoma: systematic review and meta-analysis. Am J Clin Pathol. 2013Nov;140(5):635-42. DOI: 10.1309/AJCPWSDDHLLW40WI
13. Perry MD, Seigler HF, Johnston WW. Diagnosis of metastatic malignant melanoma by fine needle aspiration biopsy: a clinical and pathologic correlation of 298 cases. J Natl Cancer Inst. 1986Nov;77(5):1013-21. PMID: 3464794.
14. Murali R, Doubrovsky A, Watson GF, et al. Diagnosis of metastatic melanoma by fine-needle biopsy: analysis of 2,204 cases. Am J Clin Pathol. 2007Mar;127(3):385-97. DOI: 10.1309/3QR4FC5PPWXA7N29
15. Cangiarella J, Symmans WF, Shapiro RL, et al. Aspiration biopsy and the clinical management of patients with malignant melanoma and palpable regional lymph nodes. Cancer. 2000Jun25;90(3):162-6. DOI: 10.1002/1097-0142(20000625)90:3<162::aid-cncr4>3.0.co;2-6
16. Hafstr?m L, Hugander A, J?nsson PE, et al. Fine-needle-aspiration cytodiagnosis of recurrent malignant melanoma. J Surg Oncol. 1980;15(3):229-34. DOI: 10.1002/jso.2930150306
17. Basler GC, Fader DJ, Yahanda A, et al. The utility of fine needle aspiration in the diagnosis of melanoma metastatic to lymph nodes. J Am Acad Dermatol. 1997Mar;36(3Pt1):403-8. DOI: 10.1016/s0190-9622(97)80216-2
18. Rodrigues LK, Leong SP, Ljung BM, et al. Fine needle aspiration in the diagnosis of metastatic melanoma. J Am Acad Dermatol. 2000May; 42(5Pt1):735-40. DOI: 10.1067/mjd.2000.103812
19. Dalle S, Paulin C, Lapras V, et al. Fine-needle aspiration biopsy with ultrasound guidance in patients with malignant melanoma and palpable lymph nodes. Br J Dermatol. 2006Sep;155(3):552-6. DOI: 10.1111/j.1365-2133.2006.07361.x
20. Voit C, Mayer T, Proebstle TM, et al. Ultrasound-guided fine-needle aspiration cytology in the early detection of melanoma metastases. Cancer. 2000Jun25;90(3):186-93. PMID: 10896332.
21. Chen L, Raza AS, Simental RG, et al. Cytoplasmic vacuoles: clue in the fine-needle aspiration diagnosis of melanoma. Diagn Cytopathol. 2014Feb;42(2):143-6. DOI: 10.1002/dc.23018
22. Gupta SK, Rajwanshi AK, Das DK. Fine needle aspiration cytology smear patterns of malignant melanoma. Acta Cytol. 1985Nov-Dec;29(6):983-8. PMID: 3866463.
23. Kapatia G, Gupta P, Rohilla M, et al. The spec-trum of malignant melanoma on cytology: A tertiary care center study. Diagn Cytopathol. 2019Oct;47(10):1018-23. DOI: 10.1002/dc.24265
24. Saqi A, McGrath CM, Skovronsky D, et al. Cytomorphologic features of fine-needle aspiration of met-astatic and recurrent melanoma. Diagn Cytopathol. 2002Nov;27(5):286-90. DOI: 10.1002/dc.10194
25. Cooper CL, Murali R, Doubrovsky A, et al. Syn-chronous and metachronous malignancies in patients with melanoma: a clinicopathologic study highlighting the role of fine-needle biopsy cytology and potential diagnostic pitfalls. Melanoma Res. 2010Jun;20(3):203-11. DOI: 10.1097/CMR.0b013e328335058b
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