The presented case demonstrates the importance of a comprehensive analysis of all the examination data in a patient with paroxysmal nocturnal hemoglobinuria (PNH). A comparison was made of anamnesis data, the clinical picture of the disease, the results of biochemical blood analysis and hematological analyzer data with morphological assessment of cells in a stained blood smear. The interest of this case for hematologists and laboratory specialists is due to the rarity of this disease, difficulties in diagnostics, the presence of 2 types of hemolysis, features of morphological changes in peripheral blood erythrocytes, as well as analysis of the dynamics of manifestations, including against the background of targeted therapy of PNH.
Dmitriy Yu. Sosnin – MD, PhD, professor at the Department of faculty therapy N 2, occupational pathology and clinical laboratory diagnostics of the Wagner state medical university, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Alevtina P. Shchekotova – MD, PhD, professor at the Department of faculty therapy N 2, occupational pathology and clinical laboratory diagnostics of the Wagner state medical university, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
Larisa S. Pavlenina – biologist of the Clinical laboratory, the highest qualification category, Perm Regional Clinical Hospital, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
Polina D. Piniagina – resident at the Department of faculty therapy N 2, occupational pathology and clinical laboratory diagnostics of the Wagner state medical university, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation. Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
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