Laboratory and Clinical Medicine. Pharmacy

Scientific and practical quarterly peer-reviewed journal

 

ISSN 2712-9330 (Online)

  • Continuous numbering: 9
  • Pages: 12-19
  • Share:

Heading: Clinical Case

Oncocytic tumors amount for about 5 % of thyroid cancer. Oncocytic differentiation of cells can be observed in various benign processes, as well as in various neoplasms of the thyroid gland (for example, in papillary, medullary carcinomas), which can cause a number of difficulties and predetermine the need for thorough differential diagnosis during cytological examination.
The article presents a clinical and morphological features of the case of oncocytic thyroid carcinoma, demonstrating the difficulties of its diagnostics at the preoperative stage and the possibility of urgent intraoperative cytological diagnostics of this tumor, the results of which correlate with the conclusion of a subsequent histological examination.
Ekaterina V. Gladysheva – MD, cytopathologist, Diagnostic Laboratory, Regional Multidisciplinary Clinical Hospital of Kursk, Kursk, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Andrey А. Kireev – MD, PhD, cytopathologist, Diagnostic Laboratory, the Yudin Clinical Hospital of the Moscow Health Department, Moscow, Russia; Russian Medical Academy of Continuing Professional Education of the Russian Ministry of Health, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
1. Coca-Pelaz A, Rodrigo JP, Shah JP, et al. H?rthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis. Adv Ther. 2021;38(10):5144–64. DOI: 10.1007/s12325-021-01876-7
2. Fariduddin MM, Syed W. Hurthle Cell Thyroid Carcinoma. In: StatPearls. Treasure Island (FL): StatPearls Publishing; February 13, 2023.
3. Zhou X, Zheng Z, Chen C, et al. Clinical charac-teristics and prognostic factors of Hurthle cell carcinoma: a population based study. BMC Cancer. 2020;20(1):407. DOI: 10.1186/s12885-020-06915-0
4. Jalaly JB, Baloch ZW. H?rthle-cell neoplasms of the thyroid: An algorithmic approach to pathologic diagnosis in light of molecular advances. Semin Diagn Pathol. 2020;37(5):234–42. DOI: 10.1053/j.semdp.2020.03.004
5. Gilani SM, Ross JA, Prasad ML, Hammers L, Cai G, Adeniran AJ. Molecular alterations in H?rthle cell neoplasms of thyroid: A fine needle aspiration cytology study with cytology-histology correlation. Cancer Cytopathol. 2021;129(5):363–73. DOI: 10.1002/cncy.22370
6. Poller DN, Ibrahim AK, Cummings MH, Mikel JJ, Boote D, Perry M. Fine-needle aspiration of the thyroid. Cancer. 2000;90(4):239–44. DOI: 10.1002/1097-0142(20000825)90:4<239::aid-cncr7>3.0.co;2-s
7. Straccia P, Santeusanio G, Pierconti F, Brunelli C, Fadda G. Cytologic Diagnosis of Oncocytic Neoplasms of the Thyroid Gland: The Importance of the Clinical Scenario. Appl Immunohistochem Mol Morphol. 2019;27(10):726–31. DOI: 10.1097/PAI.0000000000000713
8. Baloch ZW, Asa SL, Barletta JA, et al. Overview of the 2022 WHO classification of thyroid neoplasms. Endocr Pathol. 2022;33:27–63. DOI: 10.1007/s12022-022-09707-3
9. Thodou E, Canberk S, Schmitt F. Challenges in Cytology Specimens With H?rthle Cells. Front Endocrinol (Lausanne). 2021;12:701877. DOI: 10.3389/fendo.2021.701877
10. Cibas ES, Ali SZ. The 2017 Bethesda System for Reporting Thyroid Cytopathology. Thyroid. 2017;27(11):1341–6. DOI: 10.1089/thy.2017.0500
11. Yuan L, Nasr C, Bena JF, Elsheikh TM. H?rthle cell-predominant thyroid fine needle aspiration cytology: A four risk-factor model highly accurate in excluding ma-lignancy and predicting neoplasm. Diagn Cytopathol. 2022;50(9):424–35. DOI: 10.1002/dc.25000
12. McFadden DG, Sadow PM. Genetics, Diagnosis, and Management of H?rthle Cell Thyroid Neoplasms. Front Endocrinol (Lausanne). 2021;12:696386. DOI: 10.3389/fendo.2021.696386
13. Schatz-Siemers N, Brandler TC, Oweity T, Sun W, Hernandez A, Levine P. H?rthle cell lesions on thyroid fine needle aspiration cytology: Molecular and histologic corre-lation. Diagn Cytopathol. 2019;47(10):977–85. DOI: 10.1002/dc.24247
14. Valderrabano P, Khazai L, Thompson ZJ, et al. Cancer Risk Associated with Nuclear Atypia in Cytologically Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis. Thyroid. 2018;28(2):210–9. DOI: 10.1089/thy.2017.0419

The article can be purchased
electronic!

PDF format

350

DOI: 10.14489/lcmp.2023.03.pp.012-019
Article type: Research Article
Make a request

Keywords

Use the reference below to cite the publication

Gladysheva EV, Kireev AA. Intraoperative cytological diagnosis of oncocytic thyroid carcinoma. Case report. Laboratory and Clinical Medicine. Pharmacy. 2023;3(3):12-19. (In Russ). DOI: 10.14489/lcmp.2023.03.pp.012-019