Ductal breast carcinoma with neuroendocrine differentiation is a rare phenotype of invasive breast tumors. Most neuroendocrine breast tumors exhibit a luminal phenotype, positive expression of the hormone receptors estrogen and progesterone, and almost always HER-2-negative status. The article presents a rare case report demonstrating the possibilities of a complex morphological study in verifying invasive ductal carcinoma with neuroendocrine differentiation and HER-2 overexpression in a 56-year-old woman.
Andrey А. Kireev – MD, PhD, Cytopathologist, Pathology Department №3, National Medical Research Centre for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov, Moscow, Russia; Russian Medical Academy of Continuing Professional Education of the Russian Ministry of Health, Moscow, Russia.
Vlada V. Kometova – MD, PhD, Рathologist, Head of the Pathology Department №3, National Medical Research Centre for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov, Gynecology and Perinatology, Moscow, Russia.
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DOI: 10.14489/lcmp.2025.02.pp.067-072
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