A clinical case of atypical cellular protein dissociation in the study of cerebrospinal fluid in a patient with a penetrating gunshot wound to the skull and brain is described. The composition of the cells responsible for increased pleocytosis is described. The interest of this case for attending physicians and staff of clinical diagnostic laboratories (CDL) is due to the unusually high content of cerebrospinal fluid not of leukocytes, but of cells of the membranes of the brain, which was proved by the data of light microscopy of the stained preparation. In the stained smear prepared from the cerebrospinal fluid sediment, mainly cells of the arachnoendothelium, the soft meninges and vascular plexuses of the brain were found, a significant content of which caused increased cytosis during cell counting.
The problems of the clinical and diagnostic significance of the study of cerebrospinal fluid pleocytosis and the role of differential cell counting in stained cell preparations for determining the type of pleocytosis are discussed.
Dmitriy Yu. Sosnin – MD, PhD, DSc,Professor at the Department of Faculty Therapy No. 2, Occupational Pathology and Clinical Laboratory Diagnostics of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Matvei M. Barkovskii – MD, 2-nd year resident in the specialty clinical laboratory diagnostics of the Department of Faculty Therapy No. 2, Occupational Pathology and Clinical Laboratory Diagnostics of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Anna S. Blagonravova – MD, PhD, DSc, Rector of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Irina A. Bulatova – MD, PhD, DSc, Head of the Department of Normal Physiology of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Natal’ya P. Loginova – MD, PhD, DSc, Head of the Department of Histology, Embryology and Cytology of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Lyudmila A. Romanova – MD, PhD, Associate Professor, Associate Professor of the Department of Clinical Laboratory Diagnostics with a Course in Laboratory Immunology, Federal State Budgetary Educational Institution of Higher Professional Education ‘Russian Medical Academy of Continuous Professional Education’ of the Ministry of Health of the Russian Federation, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Oleg A. Sudyukov – MD, PhD, Associate Professor, Associate Professor of the Department of Normal, Topographic and Clinical Anatomy, Operative Surgery of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Larisa S. Pavlenina – biologist of the Clinical laboratory, the highest qualification category, Perm Regional Clinical Hospital, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Genrietta G. Freynd – MD, PhD, DSc, Professor, Head of the Department of Pathological Anatomy with a sectional course of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
Alevtina P. Shchekotova – MD, PhD, DSc, Professor at the Department of Faculty Therapy No. 2, Occupational Pathology and Clinical Laboratory Diagnostics of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
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