A case of severe anemia of mixed genesis is presented. The clinical picture of the disease is described, the data of laboratory investigations are given. The interest of this case for attending physicians and employees of clinical diagnostic laboratories (CDL) is due to significant discrepancies between the results of blood analysis according to automatic analysis performed using a hematology analyzer and the data of light microscopy of a stained blood smear. Various morphological changes were found in the stained blood smear, which contradicted relatively normal erythrocyte parameters (MСV, MСН, RDW) and the absence of any flags according to the hematological analyzer.
The problems of using hematological analyzer data as a basis for differential diagnosis of anemia with various disorders of erythrocyte and leukocyte morphology, especially when using artificial intelligence for decision-making, are discussed.
A. P. Shchekotova – MD, PhD, DSc, Professor at the Department of faculty therapy No. 2, occupational pathology and clinical laboratory diagnostics of the Wagner state medical university, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Y. B. Khovaeva – PhD, DSc, Professor, Head of the Department of Internal Medicine and Family Medicine of the Wagner state medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
L. A. Ivakina – doctor of clinical laboratory diagnostics of the highest qualification category of GBUZ PC “KMSCH No. 1”, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
D. Y. Sosnin – MD, PhD, DSc, Professor at the Department of Faculty Therapy No. 2, Occupational Pathology and Clinical Laboratory Diagnostics of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
V. V. Bazarnyi – Doctor of Medical Sciences, Professor, Professor of Clinical Laboratory Diagnostics and Bacteriology, Chief Researcher of the Department of General Pathology of the Central Research Institute of the UGMU; Vice-Rector for Research and Clinical Work of the UGMU Ministry of Health of Russia, Yekaterinburg, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it..
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DOI 10.14489/lcmp.2022.01.pp.017-032
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