Laboratory and Clinical Medicine. Pharmacy

Scientific and practical quarterly peer-reviewed journal

ISSN 2712-9330 (Online)

  • Continuous numbering: 15
  • Pages: 54-62
  • Share:

Heading: Clinical Case

In clinical practice, cases of metastatic thyroid disease are infrequent, and the symptoms of this disease are nonspecific, which can lead to errors in diagnosis. One of the most common secondary malignant neoplasms of the thyroid gland is renal cell carcinoma. Over the past few decades, fine needle aspiration biopsy has been considered as the main method of differential diagnosis of thyroid lesions, which determines the further tactics of patient management. Verification of a metastatic thyroid lesion can be a difficult task for a cytologist, especially if the time interval from the moment of detection of the primary lesion is quite long. This article presents cases of cytological diagnosis of metastatic thyroid lesions from patients with renal cell carcinoma.
Svetlana V. Smetanina – сandidate of мedical sciences, Head of the Cytological Laboratory Novgorod Regional Clinical Oncology Dispensary. Nizhniy Novgorod, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Evgeniya Yu. Uskova – doctor of clinical laboratory diagnostics of cytological laboratory Novgorod Regional Clinical Oncology Dispensary. Nizhniy Novgorod, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Elena N. Slavnova – doctor of мedical sciences, Leading Researcher at the Department of Oncocytology P.A. Herzen Moscow Oncology Research Institute - National Medical Radiology Research Center of the Ministry of Health of Russia, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Svetlana B. Korol'kova – doctor of clinical laboratory diagnostics of cytological laboratory Novgorod Regional Clinical Oncology Dispensary. Nizhniy Novgorod, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Margarita B. Danyaeva – doctor of clinical laboratory diagnostics of cytological laboratory Novgorod Regional Clinical Oncology Dispensary. Nizhniy Novgorod, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Kseniya Yu. Zaharova – doctor of clinical laboratory diagnostics of cytological laboratory Novgorod Regional Clinical Oncology Dispensary. Nizhniy Novgorod, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
1. Rossi ED, Bruno C, Tralongo P, et al. Updates from our institutional experience with thyroid nodules diag-nosed as metastases. Diagnostics (Basel). 2023;13(14):2388. DOI: 10.3390/diagnostics13142388
2. Ghossein CA, Khimraj A, Dogan S, Xu B. Metastasis to the thyroid gland: a single-institution 16-year experience. Histopathology. 2021;78(4):508-19. DOI: 10.1111/his.14246
3. Angelousi A, Alexandraki KI, Kyriakopoulos G, et al. Neoplastic metastases to the endocrine glands Endo-crine-Related. Cancer. 2020;27(1):1-20. DOI: 10.1530/ERC-19-0263
4. Tang Q, Wang Z. Metastases to the thyroid gland: what can we do? Cancers. 2022; 14(12):3017. DOI: 10.3390/cancers14123017
5. Stergianos S, Juhlin CC, Zedenius J, et al. Metas-tasis to the thyroid gland: Characterization and survival of an institutional series spanning 28 years. European Journal of Surgical Oncology. 2021;47(6):1364-9. DOI: 10.1016/j.ejso.2021.02.018
6. Mistelou A, Papadatos SS, Kousi C, et al. Thyroid gland as a target of secondary malignancies – an autopsy study and review data. Folia Medica (Plovdiv). 2019;61(2):277-88. DOI: 10.2478/folmed-2018-0077
7. Virchow R. Pathologie des Tumeurs. Р. Aronssohn's French translation: G. Bailli?re; 1867. Р. 544.
8. Leva J. Zur Lehre qes morbus addissonii. Arch Part Anat. 1891;125(1):35-74.
9. Slavnova EN, Baranova IB, Razmakhaev GS. Cytological diagnostics of metastatic thyroid tumors. Experience. Russian News of Clinical Cytology. 2024;28(2):33-8 DOI: 10.24412/1562-4943-2024-2-0005
10. Sevrukov FE, Isaev PA, Medvedev VS, et al. Soli-tary metastasis of the clear cell variant of renal cell carci-noma into the thyroid gland. Head and Neck Tumors (HNT). 2019;9(3):77-82. (In Russ). DOI: 10.17650/2222-1468-2019-9-3-77-82
11. Zhandarova LF, Volodina NG, Kalmykova OA, et al. Metastasis of clear cell renal cell carcinoma to the yroid gland. case report. Russian News of Clinical Cytology. 2020;24(4):19-21. DOI: 10.24412/1562-4943-2020-4-0003
12. Dolinskaya YuA, Shevchenko SP, Maksimov VN, et al. Combination of medullary thyroid cancer and renal cell carcinoma in one patient. Clinical and experimental thyroidology. 2018;14(1):34-8. (In Russ.) DOI: 10.14341/ket9259
13. Ognerubov NA, Barsukov SV, Chang VL, et al. Metastases of kidney cancer into the thyroid gland (сlinical observation). Head and Neck Tumors (HNT). 2017;7(1):91-6. (In Russ). DOI: 10.17650/2222-1468-2017-7-1-91-96
14. Zhu Y, Song Y, Xu G. et al. Causes of misdiagno-ses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review. Diagnostic Pathology. 2020;15:1. DOI: 10.1186/s13000-019-0924-z
15. Bayram F, Soyuer I, Demirici D, et al. Prostate ad-enocarcinoma metastasizing to the thyroid gland. 6 European congress of endocrinology. Lion; 2003.
16. Dequanter D, De Somerhausen N, Larsimont D, et al. The thyroid as the organ of metastatic neoplasms. 6 European congress of endocrinology. Lion; 2003.
17. Kim TY, Kim WB, Gong G, et al. Metastasis to the thyroid diagnosed by fine-needle aspiration biopsy. Clin Endocrinol (Oxf). 2005;62(2):236-41. DOI: 10.1111/j.1365-2265.2005.02206.x
18. Maly A, Meir K, Maly B. Isolated carcinoid tumor metastatic to the thyroid gland: report of a case initially diagnosed by fine needle aspiration cytology. Acta Сytologica. 2006;50(1):84-7. DOI: 10.1159/000325900
19. Domanski HA. Atlas of fine needle aspiration cy-tology; edited by Vorobyov SL. Moscow: Prakticheskaya medicina; 2022. (In Russ). ISBN 978-5-98811-677-6.

The article can be purchased
electronic!

PDF format

700

DOI: 10.14489/lcmp.2025.01.pp.054-062
Article type: Research Article
Make a request

Keywords

Use the reference below to cite the publication

Smetanina SV, Uskova EY, Slavnova EN, Korolkova SB, Danyaeva MB, Zaharova KYu. Cytological diagnosis of metastatic thyroid lesion of clear cell carcinoma of the kidney after nephrectomy in patients over 70 years of age. Clinical observations. Laboratory and Clinical Medicine. Pharmacy. 2025;5(1):54-62. (In Russ). DOI: 10.14489/lcmp.2025.01.pp.054-062