A case of ovalocytosis of peripheral blood erythrocytes in a patient with normal peripheral blood parameters according to data from a 5-diff hematology analyzer is presented. The interest of the clinical case for attending physicians and specialists of clinical diagnostic laboratories is due to significant discrepancies between the results of clinical blood analysis according to automated and non-automated assessment. Changes in morphology of erythrocytes were detected in the stained blood smear, which were not accompanied by changes in erythrocyte indices (MСV, МСН, RDW) or the appearance of signal flags on hematological analyzers.
Dmitriy Yu. Sosnin – MD, PhD, Professor at the Department of Faculty Therapy No. 2, Occupational Pathology and Clinical Laboratory Diagnostics of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Vladimir V. Bazarnyi – MD, PhD, Professor, Chief Researcher of the Department of General Pathology of the Central Research Institute of the UGMU; Vice-Rector for Research and Clinical Work of the UGMU Ministry of Health of Russia, Yekaterinburg, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Yaroslava B. Khovaeva – MD, PhD, Professor, Head of the Department of Internal Medicine and Family Medicine of the Wagner State Medical University, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Grigorii I. El'kin – MD, PhD, Associate Professor, Associate Professor of the Department of Clinical Biochemistry and Laboratory Diagnostics Military medical academy of S. M. Kirov, Saint-Petersburg, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
1. Pogorelov VM, Ivanova LA, Kozinets GI. Efficiency and informativeness of hematological analyzers. Gematologiya i transfusiologiya. 2012;57(3):30-7. (In Russ).
2. Krainova NN, Shul'ga AS, Trofimenko OV. Experience in optimizing hematological studies in a diagnostic center. Klinicheskaya laboratornaya diagnostika. 2021;66(S4):33. (In Russ).
3. Lugovskaya SA. Capabilities of hematological analyzers. Klinicheskaya laboratornaya diagnostika. 2007;2:6-9. (In Russ).
4. Diakonov DA, Rosin VA, Fedorovskaya NS. Distinc-tions of the results of automated analysis and microscopic blood investigation (examples of clinical cases). Klinicheskaya Laboratornaya Diagnostika. 2019;64(3):176-9. (In Russ). DOI: 10.18821/0869-2084-2019-64-3-176-179
5. Shchekotova AP, Sosnin DYu, Kubarev OG, et al. Problems of interpretation of the results of the study of the general blood test according to the hematological analyzer and light microscopy (clinical case). Meditsinskii alfavit. 2017;2(20(317)):39-42. (In Russ).
6. Shchekotova AP, Khovaeva YaB, Ivakina LА, et al. A case of anemia of mixed genesis with a discrepancy in the results between the 3-DIFF hematological analyzer and light microscopy. Laboratory and Clinical Medicine. Pharmacy. 2022;2(1):17-32. (In Russ). DOI 10.14489/lcmp.2022.01.pp.017-032
7. Lugovskaya SA, Pochtar' ME. Hematological Atlas 5th ed., exp. 2023. 546 s. (In Russ).
8. Dolgov VV, editor. Clinical laboratory diagnostics: v 2 t. T. 1. M.: OOO ?Labdiag?; 2017. 464 s. (In Russ).
9. Tomilov AF, Bazarnyi VV. Cytological diagnostics of blood diseases. Ekaterinburg: FGBOU VO ?Ural'skii gosudarstvennyi meditsinskii universitet? MZ RF; 2017. 123 s. (In Russ).
10. Ford J. Red blood cell morphology. Int J Lab Hematol. 2013;35(3):351-7. DOI: 10.1111/ijlh.12082
11. Sokolova NA. Modern recommendations for the unifica-tion of the system for describing morphological changes in eryth-rocytes. Spravochnik zaveduyushchego KDL. 2017;7:16-25. (In Russ).
12. Palmer L, Briggs C, McFadden S, et al. ICSH recom-mendations for the standardization of nomenclature and grading of peripheral blood cell morphological features. Int J Lab Hematol. 2015;37:287-303. DOI: 10.1111/ijlh.12327
13. Jha SK, Vaqar S. Hereditary Elliptocytosis. 2024 Feb 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publish-ing; 2024 Jan. PMID: 32966004.
14. Nixon CP, Satyagraha AW, Baird GL, et al. Accurate light microscopic diagnosis of South-East Asian ovalocytosis. Int J Lab Hematol. 2018;40(6):655-62. DOI: 10.1111/ijlh.12900
15. Sosnin DYu, Nenasheva OYu, Kubarev OG. Automated blood smear analysis systems and hematology analyzers – compet-itors or partners? Poliklinika. 2014;1-3:34-7. (In Russ).
The article can be purchased
electronic!
PDF format
700 руб
DOI: 10.14489/lcmp.2024.02.pp.047-053
Article type:
Research Article
Make a request