Cytologic screening is only effective with adequate material. The Bethesda System (TBS), an international system for standardizing the results of cervical cytology, establishes criteria for adequacy. According to the TBS, a sample prepared by liquid-based cytology (LBC) can be classified as adequate if it contains not less than 5,000 squamous epithelial cells.
There are methods of manual assessment of the cellularity of cytological samples. However, the uniformity of cellular material distribution of LBC samples makes possible the application of automatic tools for assessing the adequacy of the material based on the cellularity criterion.
This paper compares the results of digital LBC samples adequacy assessment using the automated artificial neural network method Vision Cyto Pap and the manual assessment method.
Analysis of the results of counting squamous epithelial cells in 506 LBC samples showed a significant correlation (r = 0.93) between the automated and manual method. The high diagnostic parameters (sensitivity = 93.8 % and specificity = 99.2 %) of the automated Vision Cyto Pap method allow to conclude that the algorithms of such a tool can be used to determine the adequacy of the cytological material by the number of squamous epithelium cells with sufficient reliability.
Karine T. Kasoyan – associate professor of the Department of Clinical Laboratory Diagnostics with a course of laboratory immunology at Federal State Budgetary Educational Institution of Further Professional Education ?Russian Medical Academy of Continuous Professional Education? of the Ministry of Healthcare of the Russian Federation (FSBEI FPE RMACPE MOH Russia), clinical laboratory diagnostician (cytologist). Member of the International Academy of Cytology (MIAC), Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Irina P. Shabalova – professor of the Department of Clinical Laboratory Diagnostics at Federal State Budgetary Educational Institution of Further Professional Education ?Russian Medical Academy of Continuous Professional Education? of the Ministry of Healthcare of the Russian Federation (FSBEI FPE RMACPE MOH Russia), clinical laboratory diagnostician (cytologist). Member of the International Academy of Cytology (MIAC), Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Vladislav A. Sapozhkov – Engineer of the analytical systems group of the service center LLC 'Medica product'; Head of R&D Department, International Cytology School&Innovatory Medical School, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Anna S. Churilova – Head of the Artificial Intellegence Development Group of the Software Development Department LLC ‘Medica Product’, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Maksim S. Lubnin – software developer of the Software Development Department LLC ‘Medica Product’, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Boris F. Falkov – Head of the Artificial Intellegence Development Group of the Software Development Department LLC ‘Medica Product’, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
1. Clinical guidelines "Cervical intraepithelial neoplasia, erosion and ectropion of the cervix. 2020. Ap-proved by the Ministry of Health of the Russian Federation.
2. The Bethesda System for Reporting Cervical Cy-tology. Third Edition. Editors: Ritu Nayar, David C. Wilbur, 2015.
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DOI: 10.14489/lcmp.2023.02.pp.012-018
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