Восточная Европа и Россия относятся к регионам с высоким уровнем инфицирования вирусом папилломы человека (ВПЧ) – инфицированы около 22 % населения, при этом отмечается неравномерное распределение видов вируса по регионам и социальным группам. Наиболее частыми онкологическими заболеваниями, диагностируемыми вместе с ВПЧ, являются: рак анального канала – 80 %, рак влагалища – 70 %, рак ротовой полости и глотки – 30 %, рак полового члена – 50 %. На примере зарубежного опыта диагностики рака шейки матки и плоскоклеточного рака головы и шеи показана роль различных лабораторных методов и их комбинаций в диагностическом поиске вируса папилломы человека высокого канцерогенного риска. В обзоре представлены диагностические возможности генотипирования, иммуно-цитохимического окрашивания маркеров p16/Ki-67, методы метилирования ДНК, гибридизация in situ на клеточных блоках, молекулярные методы амплификации нуклеиновых кислот, а также экспресс-метод определения онкопротеина Е6.
Г. А. Милованова – ординатор кафедры клинической лабораторной диагностики РМАНПО, Москва, Россия. E-mail: Адрес электронной почты защищен от спам-ботов. Для просмотра адреса в вашем браузере должен быть включен Javascript.
К. Т. Касоян – к.м.н., доцент кафедры клинической лабораторной диагностики ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФ (РМАНПО), врач клинической лабораторной диагностики (цитолог). Член Международной Академии Цитологии (MIAC), Москва, Россия. E-mail: Адрес электронной почты защищен от спам-ботов. Для просмотра адреса в вашем браузере должен быть включен Javascript..
О. И. Пацап – к.м.н., заведующая патологоанатомическим отделением ФГБУ «Федеральный центр мозга и нейротехнологий» ФМБА, Москва, Россия. E-mail: Адрес электронной почты защищен от спам-ботов. Для просмотра адреса в вашем браузере должен быть включен Javascript..
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