VOL 3, No. 4 (2023)

In order to automate microscopic examinations of female urogenital samples, the “learning” of the “Vision Cyto STD” system was performed using the technology of image recognition based on convolutional neural networks and deep learning.
More than a thousand digital slides with urogenital material with different microscopic composition were evaluated during the learning process. As the dataset was replenished with new clinical examples, the accuracy of object recognition increased.
The use of artificial neural networks (ANN) for imaging and analysis of urogenital samples ensures high quality of examination performance due to the clarity of identification, accuracy of analysis and correctness of entering the examination results. Using of ANN speeds up the process of giving the results, allows to minimize the influence of the subjective factor, and also provides an opportunity to redistribute the workload of laboratory workers, without expanding the laboratory staff when the number of examinations to be performed increases.
A brief overview of the automated Vision Cyto STDs system is presented.

The availability of drug therapy for post-stroke patients during outpatient treatment is an important aspect of ensuring the timeliness and quality of medical care. In this regard, this paper presents the results of assessing the physical and affordability of pharmacotherapy in patients who have suffered an ischemic stroke. The data obtained show a high level of physical availability of the studied medicinal resource, both in the regional (Kursk) and the Russian pharmaceutical market. At the same time, the price availability of the range of medications prescribed for rehabilitation and secondary prevention of stroke has a significant variation. A list of medicines has been established that have a very high cost in the pharmaceutical market of the country and, accordingly, low price availability for the population.

The article is devoted to the study of internal disease picture in patients with urolithiasis. The authors studied the emotional state and characteristics of the response of patients with urolithiasis to their disease. The study presents data on the types of patient responses to stress depending on the personality characteristics of the patients and the course of the underlying disease. The patient’s attitude towards his health and the fact of the occurrence of the disease are also different and largely determine the duration, course and prognosis of disease. The personal significance of disease is one of the components of psychosocial reaction to disease, the features of which are also presented in the work. Much attention is paid in the article to the features of the psychological portrait of a urological patient and the emotional state of urological patients.

There is a barrier to understanding the causes of infertility in couples timely due to asymptomatic picture of high risk human papillomavirus (hrHPV) in men. Concerning to recent research, hrHPV capsids bind efficiently to two distinct sites at the equatorial region of the sperm head surface. The clinical case demonstrates the role of sperm sediment cytology in diagnostics of hrHPV that was confirmed by hrHPV screening test by nucleic acid amplification technique (NAAT) with polymerase chain reaction in real time (RT-PCR) (NAAT/ RT-PCR/hrHPV).

Lung cancer (LC) is a widespread malignancy diseases that occupies a leading position in the structure of morbidity and mortality among cancer patients worldwide. It is characterized by detectability at late clinical stages and an unfavorable prognosis. Primarily, the diagnosis of LC is based on the results of morphological methods. Cytological examination takes a key position in general morphology examination due to a highly informativeness and minimally invasiveness.
The cytological method of LC diagnosis has proven itself for several decades as highly informative and economical, fitting into the modern strategy of minimally invasive diagnostic procedures. A whole spectrum of samples is applicated for cytological examination for LC diagnosis the characteristics of which are presented in this review.

Chronic endometritis (CE) is a persistent inflammation of the endometrium, which can lead to infertility and other reproductive disorders. The diagnosis of CE is based on various histological criteria, the main of which is the presence of stromal plasma cells, however, standardized methods for their assessment have yet to be investigated.
In this review, we will discuss modern approaches to the verification of endometrial stromal plasma cells, as well as methods of its objectification using various immunohistochemical markers and methods based on artificial intelligence.