Laboratory and Clinical Medicine. Pharmacy

Scientific and practical quarterly peer-reviewed journal

 

ISSN 2712-9330 (Online)

VOL 1, No. 1 (2021)

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    Chief's Page

  • Welcome messages

    • Pages: 1-7
    • Views: 311

    Greetings to readers, authors and editorial board members

  • Editorial Article

  • VIRAL EFFECT OF SARS-COV-2 ON MALE INFERTILITY

    • Pages: 8-13
    • Views: 345

    Clinical laboratory diagnostics of male infertility is an integral part of the diagnostic process in the field of reproductive medicine. Studies conducted during the pandemia of novel coronavirus infection (COVID-19) indicate that RNA of SARS-CoV-2 can be detected in the testes, and that the possibility of disrupting spermatogenesis and the viral impact on male reproductive health has been predicted.

  • Economics and Management in Medicine and Pharmacy

  • ANALYSIS OF MANAGEMENT RISKS IN THE ORGANIZATION OF CORPORATIVE HEALTHCARE SYSTEMS IN THE UNFAVORABLE EPIDEMIC SITUATION IN RUSSIA AND GERMANY (2020-2021)

    Autors:

    S. V. Mironov

    • Pages: 14-21
    • Views: 323

    Risk management in healthcare is studied insufficiently. Risk management will provide more accurate forecasting and planning, it will improve quality of management decisions and increase the efficiency of medical organizations. The necessity of developing health systems has become relevant both in Russia and abroad in the context of the coronavirus pandemic 2020-2021. There is an increased interest in reviving and improving of corporate health management systems of large enterprises. The author was consistently engaged in the organization of health care in 3 large federal companies in Russia, as well as in Germany during the pandemic. The specific tasks of corporate health care in the context of a pandemic, the criteria of management errors and typical management errors were identified and classified, their primary causes were established. General recommendations were given based on the analysis, directions for the development for the further study were formulated.

  • PERSONNEL MANAGEMENT IN CONTEXT OF ANALYSING THE PHARMACISTS’ PERSONALITY TYPES

    • Pages: 22-28
    • Views: 354
    Studies have been conducted to optimize the processes of personnel management in pharmacies, to determine the relationship between the type of a pharmacist’s personality and the availability of organizational and career competencies. In order to determine the competencies necessary for the work performed, the analysis of the specifics of the pharmacists’ work (at the examples of a manager, a pharmacist with higher education, and a pharmacist with secondary professional education) has been carried out. An expert assessment of the questionnaire has been made to assess the significance of five clusters of competencies (will and leadership, interpersonal communication, organizational and strategic skills, self-positioning) in relation to the specifics of the activities at the pharmacy. The relationship between the positions of specialists and the level of development of their competencies has been determined and expressed quantitatively (from 1 to 5 points). There is a low correlation between the indicators of the competencies of the managers and pharmacists. It confirms the need for differentiation in the formation of sets of competencies for training the specialists.
    Based on the Lominger competencies model and the results of expert research, the ‘Personality type – position’ matrix for a pharmacy’s manager has been constructed. A personality type was determined by means of the questionnaire of Myers & Briggs test. An algorithm for determining the optimal personality type of a candidate for the position of manager has been presented. Similar calculations can be made for pharmacists with higher education and pharmacists with secondary professional education. The data obtained make it possible to use them in the determination of a working place, hiring, and rotation of specialists.
  • Original Articles

  • THE CONCENTRATION OF INTERLEUKIN-6 AND INTERLEUKIN-8 IN HUMAN SEMEN WITH HIGH VISCOSITY

    • Pages: 29-39
    • Views: 327
    Objective: to estimate the effect of ejaculate consistency on the levels of interleukin-6 and interleukin-8 in human seminal plasma.
    Material and methods. The concentration of interleukin-6 and interleukin-8 was determined by ELISA using the kit manufactured by ?Vector-Best? (Russia). The study included 64 men: the main group (n = 30) presents patients with high semen viscosity, the comparison group (n = 34) presents men with normal semen viscosity.
    Results. In average, interleukin-6 level in the semen was 13.45 pg/ml, the median was 13.79 pg/ml; the data ranged from 8.24 pg/ml to 19.34 pg/ml. In average, level of interleukin-8 was 28.9 pg/ml, the median – 13.96 pg/ml; there is a large range of values from 0.202 pg/ml to 174.5 pg/ml. There are no significant differences in the values of interleukin-6 and interleukin-8 of the main group from the comparison group: for interleukin-6, U = 377.0 (p = 0.074655); for interleukin-8, U = 407.0 (p = 0.863852). The data obtained did not correlate neither between groups nor with the fertility markers of the human semen.
    Conclusion. Interleukin-6 and interleukin-8 levels in the human seminal plasma do not depend on semen viscosity.
  • APPLICATION OF NEURAL NETWORKS IN MEDICAL DIAGNOSTICS

    • Pages: 40-51
    • Views: 334
    This article discusses the possibilities of application of artificial neural networks to solve problems of increasing the diagnostic outcomes in clinical laboratory examination. High diagnostic sensitivity (96 %) and diagnostic accuracy (89.5 %) of the results were shown on a large amount of cellular material digitized by artificial intelligence microscopy automation system like the Vision Cyto Pap.
    The high resolution and sharpness of digital slides, the mode of viewing objects (cells) in the gallery, quick access to the results of preclassification, all of these factors together allow to reduce turnearound time in more than 2.5 times reducing disadvantages of the microscopy.
    Application of artificial neural networks does not substitute a doctor’s skills. The role in validation of reports eligible only for cytopathologist. This concept indicates a carefully approach for staff working with a microscope, respectful attitude to them professional skills, and highlights a personalized approach to patients..
  • Abstract Reviews

  • RENAL COMPLICATIONS OF COVID-19 CORONAVIRUS INFECTION: MECHANISMS AND BIOMARKER

    Autors: V. V. Velkov
    • Pages: 52-56
    • Views: 302
    The brief review dealing with risks of the development of renal complications in patients with COVID-19, peculiarities of acute kidney injury development in patients with coronavirus. The special attention is given to the mechanisms of the direct infection of kidney by coronavirus SARS-CoV-2 and to the biomarkers for differential diagnostics of glomerular and tubular dysfunction in patients with COVID-19..
  • Review Articles

  • LABORATORY DIAGNOSTICS OF MALE INFERTILITY. BIOMARKERS. PART I

    • Pages: 57-68
    • Views: 358
    Currently, clinical laboratory diagnostics of male infertility is an integral part of the diagnostic process in the field of reproductive medicine. This review provides information about novel and traditional immunological, cellular, biochemical and other markers of human semen, which are used in the complex laboratory diagnostics of male infertility. Unfortunately, at present, due to the lack of updated clinical guidelines for male and female infertility diagnostics, uninformative algorithms and incompatible assessment criteria are increasingly used. This situation leads to controversial discussions, where the diagnostic functions of laboratory tests and markers are questioned. That is why the constant search is needed for innovative diagnostic approaches aimed at in-depth study of the pathogenesis of male infertility and subfertility.