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Created: 25 December 2023

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• VOL 3, No. 4 (2023)

The article is devoted to the study of internal disease picture in patients with urolithiasis. The authors studied the emotional state and characteristics of the response of patients with urolithiasis to their disease. The study presents data on the types of patient responses to stress depending on the personality characteristics of the patients and the course of the underlying disease. The patient’s attitude towards his health and the fact of the occurrence of the disease are also different and largely determine the duration, course and prognosis of disease. The personal significance of disease is one of the components of psychosocial reaction to disease, the features of which are also presented in the work. Much attention is paid in the article to the features of the psychological portrait of a urological patient and the emotional state of urological patients.

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Created: 30 September 2023

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• VOL 3, No. 3 (2023)

This paper is lecture which deal with the importance of laboratory examination for oral fluid so called “salivadiagnostics”. This paper is clarifying the preanalytical stage (obtaining, storing and transfer of samples) and chemical-microscopic methods (pH, relative density, leukocytes, erythrocytes, protein, glucose) for performing a “dry chemistry” technology. The features some of them and changes of parameters in various diseases (neuropsychiatric, dental, pathology of internal organs, osteoporosis and other ones) are presented.
The problems of clinical interpretation of changes of oral fluid as well as future prospects of non-invasive diagnostics have been discussed.

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Created: 05 July 2022

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• VOL 2, No. 2 (2022)

The review presents novel insight on the cells of normal and pathological synovial fluid (SF) which detected by light microscopy, as well as the diagnostic value of some biochemical markers of SF which can help in the differential diagnosis of diseases musculoskeletal system [1]. Early diagnosis will help to start timely treatment at the primary stages of the disease. The clinical lecture notes the pathway for standardization of laboratory procedures in SF examination в for conventional practice of medical lab in Russia.

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Created: 24 March 2026

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• VOL 6, No. 1 (2026)

The lecture addresses issues related to the cytological diagnosis of pathological changes in the glandular epithelium of the uterine cervix. The cytological criteria for the categories AGC-NOS (atypical glandular cells, not otherwise specified), AGC-FN (atypical glandular cells, favor neoplasia), AIS (adenocarcinoma in situ), and invasive adenocarcinoma of the endocervix and endometrium are described. For each category, key cytological characteristics are described, including group architecture, nuclear features, cytoplasmic features, and background characteristics. The diagnosis of glandular epithelial lesions remains a challenging task requiring a high level of cytological expertise. Improvement in diagnostic accuracy can be achieved through the use of liquid-based cytology, adherence to the standardized Bethesda System, continuous professional development, and the implementation of new technologies.

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Created: 21 September 2022

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• VOL 2, No. 3 (2022)

Breast cancer is a very important problem affecting the female population worldwide. The immune system is a determining factor in the emergence, development, and progression of the tumor process. Its role is described by a concept such as immunоediting. Immunоediting implies that clinically relevant tumors have developed mechanisms to bypass immune control and cause the body to tolerate them. Understanding of the interaction between cancer cells and regulatory immune pathways should provide the basis for effective immunotherapy for breast cancer.

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Created: 28 December 2021

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• VOL 1, No. 2 (2021)

Synovial fluid examination plays the important role in diagnosis and treatment of joint diseases. Nowadays it presents a substantial challenge in clinical and lab settings because of lack of manuals for the examination and processing
of synovial fluid. It needed cross-disciplinary approach between orthopedic and trauma surgeons, rheumatologists, general practitioners, and clinical lab specialists to achieve the diagnostic and treatment spot-on goals in time. It is become incredibly important to develop the standard procedures for assessment of synovial fluid and its implementation into the practice for clinical diagnostic laboratories.