Laboratory and Clinical Medicine. Pharmacy

Scientific and practical quarterly peer-reviewed journal

ISSN 2712-9330 (Online)

  • Continuous numbering: 15
  • Pages: 63-67
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Heading: History of Medicine and Pharmacy

In this review, authors conduct a short fragment of an in-depth analysis of the 6th Edition (2021) of the WHO procedural manual for human semen analyses comparing with 5th Edition (2010) one. Highlighting the pitfalls we clarify the key points of problems. Also, authors note the well way for basic semen examination for laboratory in Russia at the present time.
Zhanna Yu. Sapozhkova – MD, PhD, Editor-in-chief Laboratory and clinical medicine. Pharmacy journal, Head of International Cytology School, Senior Lecturer, Moscow, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Dmitriy Y. Sosnin – MD, PhD, DSc, Professor at the Department of faculty therapy № 2, occupational pathology and clinical laboratory diagnostics of the Wagner state medical university, E. A. Vagner Perm State Medical University, Ministry of Health of Russian Federation, Perm, Russia. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
1. World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th ed. WHO Press: Geneva, Switzerland, 2010.
2. World Health Organization. WHO laboratory manual for the examination and processing of human semen. 6th ed. Geneva: World Health Organization; 2021.
3. Boitrelle F, Shah R, Saleh R, et al. The sixth edition of the WHO manual for human semen analysis: a critical review and SWOT analysis. Life. 2021;11:1368. DOI: 10.3390/life11121368
4. Sapozhkova ZhYu. Semen examination on the national way. Laboratory and Clinical Medicine. Pharmacy. 2024;4(4):14-25. (In Russ). DOI: 10.14489/lcmp.2024.04.pp.014-025
5. Pis'mo Ministerstva zdravookhraneniya Rossijskoj Federacii ot 8 aprelya 2024 г. N 17-6/I/2-6434 ‘O napravlenii metodicheskikh rekomendacij po dispanserizacii muzhchin i zhenshchin reproduktivnogo vozrasta s cel'yu ocenki reproduktivnogo zdorov'ya’. (In Russ).
6. World Health Organization. WHO Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. Cambridge University Press: Cambridge, UK, 1999. P. 96-9.
7. ‘Klinicheskie rekomendacii ‘Muzhskoe besplodie’ (utv. Minzdravom Rossii), razrabotchik: obshcherossijskaya obshchestvennaya organizaciya ‘Rossijskoe obshchestvo urologov’, odobreno Nauchno-prakticheskim Sovetom Minzdrava RF, 2021г. (In Russ).

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DOI: 10.14489/lcmp.2025.01.pp.063-067
Article type: Review
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Sapozhkova ZhYu, Sosnin DYu. Semen Examination History: Pitfalls of WHO Laboratory Manual of The Fifth and Sixth Edition. Part II. Laboratory and Clinical Medicine. Pharmacy. 2025;5(1):63-67. (In Russ). DOI: 10.14489/lcmp.2025.01.pp.063-067