Objective. To study the microbiological profile of pathogens causing urinary tract infections (UTI) in children in Perm and to characterize the sensitivity of isolated urocultures to antibacterial drugs used in pediatric practice. Materials and methods. The material for the study were strains of uropathogenic microorganisms isolated from the urine of patients of the city children's nephrology department. Urocultures were isolated by the sector sowing method, the EUCAST disk diffusion method was used to assess antibiotic sensitivity. Statistical processing was performed in the Microsoft® Excel application. The results. The structure of isolated uropathogens was dominated by E. coli, Enterococcus faecalis, St. Epidermidis, Enterobacter aerogenes, Klebsiella pneumonia. When analyzing the sensitivity of the isolated strains to antibacterial drugs, it was found that most representatives of gram-negative microflora were sensitive to second- and third-generation cephalosporins, and the sensitivity of E. coli urocultures to amoxiclav remains. Conclusion. Studies have shown that in the structure of pathogens of UTI in children, there is an increase in the proportion of gram-positive microorganisms, which reflects global trends associated with the formation of antibiotic-resistant, hospital strains circulating in the child population against the background of changes in population immunity.
Polina V. Kosareva – DM, professor of Childhood Diseases Propaedeutics Department, Perm State Medical University named after Academician E. A. Wagner; professor of Inorganic Chemistry, Chemical Technology and Technosphere Safety Department, Perm State University, Perm, Russia; doctor of clinical laboratory diagnostics at Children's City Clinical Hospital named after P. I. Pichugin, Perm, Russia.
Dmitry A. Bondar – Chief Physician of Children's City Clinical Hospital named after P. I. Pichugin, Perm, Russia.
Natalya N. Pankova – the head of City Hospital Nephrology Department at Children's City Clinical Hospital named after P. I. Pichugin, Perm, Russia.
Ludmila V. Sivakova – PhD, associate professor of Pathological Physiology Department, Perm State Medical University named after Academician E. A. Wagner; associate professor of Inorganic Chemistry, Chemical Technology and Technosphere Safety Department, Perm State University, Perm, Russia.
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DOI: 10.14489/lcmp.2025.02.pp.051-057
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